In my quest for a set of speakers, I tried the Opals. At first, I was really impressed by the product. But after 2 days, IO realized my mixes were not translating at all, and that I was pushing the mid-range like crazy. Everything was stuck here, and it was really unpleasant to hear. I slowly started to switch back to the studio monitors (BM15A, which I don't like very much for their woofie, bass and carved low-mids), and ended up not using the Opals at all. When I got to the mastering, I realized it had been for the best...
That's my experience with the Opals. I never tried them in another room, though.