Hey Guys, just thought I'd chime in here.
I recently bought a Big Knob Passive and connected it to my Motu Ultralite MK4. I used this set up for around 1 month, never going directly into the interface since I bought it. I am running all Mogami Gold cables, and ran Mogami Gold patch cables (3ft) to connect the interface to the Big Knob. From there I ran my Adam A7X's to the Big Knob with 6 ft Mogami Gold's. After running it this way, I decided to try the Adam's directly into the interface and let me tell you... The Mackie does in fact degrade the sound quality. I didn't want this to be so, as I really liked having a stand alone volume controller, and was excited to run a passive unit (thinking it would not affect the sound quality), however - it did make a huge impact and I immediately removed it from my chain / set up. This change is so noticeable, that I had to turn my tweeter level down to almost -4 (9 o'clok) and my high shelf down to 11 o'clock, where before everything was at 0.
To be honest, I was very happy with the sound of the A7X's and the big knob, but not until I ran them directly into the Motu did I really get the full sound of my monitors / source material - Especially on the high end / mids (as well as the lows and stereo image, depth & detail). Now, I have a new found respect for the Adam's.
What's worse? I did a shoot out this way with a pair of Adam A7X's and Genelec 8040's... Should I have kept the 8040's? Only Mackie can tell you... Or another proper shootout. Be warned... If you are looking for pristine audio quality, then I would suggest not using this product. If solely volume control is something you are after, I believe it's useful - however, for serious audio engineering and or production, I would not recommend it.