No, I have only one U5, I use mostly for the minimoog.
For the other synths I use just a behringer ultra-DI pro before it goes to the dedicated inputs of the ensemble. I use two by the way, because I have extra adat inputs with my ensemble (so I have 16 inputs total).
Sometimes I use my mackie (24-4) to merge some layers before go to the apogee. In this Jam for example, I run everything to the mackie.
https://www.youtube.com/watch?v=Zo4PFRwMpPo
And yes, I prefer to put my gear directly into my FX pedals and delays.
A guitar pedal for example, react very differently when a synth is directly put into it (other than route this with an analog board with send/return)
The difference is quite big if you have a chain of pedals that interact on each other (specially the overdrive, fuzz and distortion).