You'll get a better so what response if you post this in the guitar subforum.
__________________ "make multitrack sound for long long time" "I don't understand this shootout. May I borrow your ear canals so that we're on the same page?" "Lofi is an artform....not a sample rate""
Both single coil but totally different sounding. Traditional strat pickups have that, or should have that, distinctive bell-like sound. Whereas, P90s are more agressive, in a good way. P90s are classic sounding pickups. I prefer them to PAF 57s or Burstbuckers.
I don't know the technical words, but start pickups have this distinct peak that just seems to cut through. P90's are thicker and and less chimey. Still great as singles, but a thicker tone which has a nice overdriven grind. I consider p90's to fit in the middle between a single in a Tele, and a low output HB.
On a strat... I'm a fan of HSS ... single coil on the middle and neck, and humbucker in the bridge. You can get beefy with the humbucker with tone rolled off.
The only sacrifice is position 2 (the quacky sound).