I would look for a combo back cabinet both for sound and for versatility as long as you're running a low to mid level power amp. 5-40 watts
Check out the ported cabinets from Tone-Tools
and the variety of custom cabinet designs at Vintone.
Also take a look at rawoods.com
His combo cabinet is very nice.
Shown is a solid pine 2X12 Fender reproduction cabinet with a nice upgrade.
I'm wishing I had a set-up with 1 Vintage 30 and 1 Tone Tubby Hemp Cone
or the more affordable Eminence Wizard or maybe the Weber Thames.
Mixing two compatible speakers can give you a nice blend of the best
of the two speakers combined or individually at reasonable volumes.
A combo speaker cabinet run either mono or stereo/mono would also give you a variety of tones to choose from.
If you're running class A, you can do amazing things with 8" and 10" speakers.