Cubase 4, mac pro symphony AD16x here.. No da from apogee yet though, so my latency issues are unsolvable.
I can create a joint driver between symph and the core audio for output but I dont' think they communicate latency problems correctly.
As far as ease of use and setup it was so easy i couldn't call it a setup, other than installing the cards. The computer ran with the ad16x right as i installed it and cubase was very happy.
I anticipate when i grab another apogee unit i'll have no latency problems at all.