I use a 1" square double sided pcb mounted with a dual opamp. 1/2 is the signal preamp, the other 1/2 does phase reverse cancellation, pre-conditioned to remove those hum harmonics, 60, 120, 183, 250 hz.
That feeds a trimpot. Rotate it and all the hum drops off, to about -80 dbu.
I use an import plastic strat bobbin removed of all metal for the dummy coil, the closer it matches, the deeper the hum null.
I use original 1960's era Fender Tele pickups, with a -80 dbu s/n ratio, not too shabby.
Everything is screened and the pickups are shock mounted. I play on "11" but have no noise and complete stability, tough with a Telecaster
. I do Hendrix like controlled feedback, but on a Telecaster
. Yes, it can be done, it's been done here for over 20 years.