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I use Cubase at home... Live? depending on the job but i think i would have to go with eXT... or a combo of Cubase, Live and eXT.
I reread your post, you are on Mac so no eXT... well it´s a VST host\subhost that run on PC, very intuitive and easy to setup and yet powerfull enough to convey MIDI and audio streaming.
So in your case i would go with Cubase. Kraftwerk do it live with Cubase.
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