| Dude, VHT power amps. They're built like tanks and they sound awesome. I realize you're new to the power/pre thing, but think of it like this; when you have a combo or a head, everything is integrated. You have more opportunities for tonal variety with a pre/power amp.
I'm not trying to shut anyone down here, but some of the disadvantages listed are a little odd to me. You can fit most power and preamps into a four-space rack ccase. If you want a power conditioner, which I personally swear by, get a six-space and you have an extra rack space for a tuner, wireless, processor, whatever your Slutty heart desires. The rack case basically becomes your new "head". You leave everything hooked up internally and tuck the power and speaker cables in when you're moving.
There is no more neccessity for a stereo setup than there is with a normal head and the weight difference can be negligible. If you really like the options afforded to you bu the 2101 then hook up with a sweet power amp and rock out. I may be newish to the studio side of Sluttiness, but I have plenty of experience with guitar rigs. In fact, if you have any questions then feel free to PM me.
Best luck.
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