Hello ,if you could post more details about your box maybe i could help
Which motherboard,additional PCI/USB/whutever devices 're inside etc . Also more details about "digital grunge" .Whut kind of noise is it eh?When exactly does it happen ?
Usual causes for that can be ****en VIA chipset mobos (its PCI bandwidth shite),sharing audio cards with shitty modems ,early intel mobo USB controllers with anything cheap on it,etc ...
I presume it is properly clocked and not running on ultra low latency buffer.Weird things DO happen in every ****en PC i've worked on ,evil is in them chips for sure ,but usually they cant resist Jedi mind power mouse clicks or screwdriver in the end.