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Sure, its no problem to use some audiophile speakers for mixing, as long as they have flat(ish) response, and great imaging. Personally, I use a pair of ATC SCM-50A active triamps, and can't imagine mixing on anything else (right now). These speakers image better than anything else I've heard, and have nice broad dispersion (you can even mix well off axis). The ATC's are somewhat flat sounding with a tight and fast bass though (a brittish sound), and if you're used to aggressive bass sounds you may not like them.
Magneplanars or Sonus Fabers would be cool too in my books.
Like thethrillfactor said, you just need to find the right audiophile speaker. The same rules apply for auditioning 'pro' monitors...bring in some mixes you know, and evaluate them.
Good luck, and cheers,
Kris
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