[octatonic]

It is a really distorted tone- sounds like an Octavia type circuit to me.
If I was trying to cop this sound I would do the following.
Strat on neck pickup into octavia or voodoo lab Proctavia into big muff or similar then into a class A tube amp (I have a 63 Bassman head)
Then close mic it with a 57 into a nice tube mic pre.

It sounds like there has been a bit of filtering/eq done post tracking too.

You could try going direct with an octavia/proctavia and then using an amp sim if you are on a budget.

You might want to check out some of Jeff Beck's playing- it sounds like that is what they are trying to cop. Check out the tones on Wired or Blow by Blow.

It is all in the playing though.

Hope this helps.