A DIY version would be easy to make work on different screens. It could just be the pots / cable housings / a drilling template for everyone to adjust for their specific needs. Then you would just measure and print out a drilling template for the plexiglass. As the pots would actually be just encoders without the motors, the whole "kit" would cost next to nothing.
Edit: The "brain" could be a fairly simple
Midibox 64 or something similar.
But the software is the real issue.
To be done right this would require a midi software that could mimic mackie controller(s) for the sequencer and be fully configurable on the inside. The software should allow users to freely map any parameter to any pot and modify the graphics to suit the purpose of the pot too.
It would make sense to incorporate the possibility to hook up other midi controllers to the software too.
That way it could have motorized faders underneath the pot-equipped screen also, and if one wishes, one could add a few more screens too... The software would be like a modular midi control surface mainframe.
To be done really properly such software should operate on something like EuCon protocol. Something that allows it to communicate with the DAW using ethernet instead of midi.
I would have started this already myself if I could program such software. The screen / pots / graphics part is easy. But the software is what makes or breaks it.