Have had 2 LaCie drives die on me - the actual drives are always fine, but the build quality / connectors and chip sets used by Lacie have always been to blame. Will never trust them with my data again.
So, now I've got a Glyph GT050Q and an Avastor HDX - both are quad interfaces, have internal power supplies (praise the Lord!

) and are built like tanks. Yes, they're more expensive than everything else. Yes, they use the same hard disks as everyone else. But in the case of Glyph, you're getting the peace of mind of their free data retrieval service should everything go tits up, and with Avastor....er, they look nice and come in a sexy black case.
Seriously though, the Glyph has been used almost everyday, 12 hours + for the last 5 years, without a hiccup. The Avastor is into year two, same story. I'd recommend either without reservation.