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I'm working at 32 samples of latency more and more. Using an RME RayDAT card with Logic 9 on an 8-core Mac Pro. Once you get to 32 samples, you're in the ballbark of TDM systems anyhow.
I've done several live shows, doing a submix of instruments and voice from the stage at 32 samples of latency with a FF400 as well. Sometimes I use 64 samples on stage; that doesn't seem to pose much of a problem as far as noticeable latency in the monitor mix.
Seems to me like native systems are either all the way there or very nearly there at this point, with the right audio interface.
-synthoid
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