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A couple of Factual points:
1) If you connect iMac <-> FW800 HD <-> Mobile I/O using a FW800 cable to the HD, the computer will communicate with the dive at FW800; it does NOT slow the entire bus down to FW400. Communications with the MIO will be at FW400, but that is not an issue, especially for one box.
2) RME's TotalMix does not do anything to reduce the latency when processing with plugins on the host. If you need processing, you will incur the host latency if you use the FireFace 800.
Since you can run plugins on the hardware on the MIO, you do not incur any additional latency from processing when you are using the MIO plugins.
FW800 has no impact on the audio latency.
Hope this helps.
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B.J. Buchalter
Metric Halo
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