yes hits have been made with both (for all the haters lol) so let's see here:
all of 9th wonder's early productions including "Threat" (Jay-Z "Black Album) -> now he's on the mpc 2500 though
all of dj khalil's recent productions including "Kinda Like a Big Deal" (current Clipse single) done in Reason. He often gets musicians to play into PT then he chops it up in Recycle and then transfers to Reason
all of dj babu's recent productions done in Reason
many of DJ Toomp's productions including TI "What You Know" and Kanye West "Big Brother" done in Reason
other professional fl users:
Power Users
whatever software / hardware you can think of has been used for hits. quit being biased about a particular piece.