I've used DP 5.13 with Symphony on my Quad G5 and it was rock solid, really a great setup. You don't even need Maestro...I myself never really got my head around it, I just monitor straight through DP at a 64 buffer. My 2408 is on another computer that is being used as a sound module.
I'm switching over to Logic, but the 64 buffer in DP is more than sufficient. Just take out the 2408 from the chain. You could probably do what I did, switch the rosetta for an AD16X and hook it up digitally through the D8B. I don't know the quality of the DA from that desk, but my Yamaha was good enough for me that I didn't need a separate DA. Save you a couple grand that way, as well as double your analog inputs.
That said, the 2408 is really a good system, and their Cuemix could have been really something had they developed it even more. Great bang for the buck. But if you have and like Apogee interfaces, adding the Symphony card is close to a no-brainer...(if only it was a bit cheaper!)
