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I use a Presonus FP10, my MBP, and Live 8 which handles vocals, direct bass, submix of synths (Mackie LM3204), 12 string acoustic guitar, backing tracks, and video with full automation of effects (delay, chorus, reverb, ect..). The FP10 also handles the output mix for FOH, the drummer, and to the QSC powered monitors we use on stage.
In my 3 years of using my MBP (since Live 6) I have had a 100% success rate. My keyboard player uses a Vista HP notebook for just for live soft synths and constantly has problems even at rehearsals. We plan on getting him a white MB very soon. Others may have a different story, but I would never trust a Vista notebook to handle my gigs.
If you just need 2 ins and outs I would suggest a Macbook and an Apogee Duet.
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