I record voice-overs for commercials etc every day. Just finishing up the new Philips Demo DVD for 2009 here in 15 languages...
I use a Sennheiser 416, cuts through everything. That's basically all the gear I use when treating VOs (the talent is half the work), the rest are plug-ins.
Some compression (fast attack, fast release), 80 Hz cut, 250Hz dip, 2k shelf boost (maybe a little peak at 11k-13k) and sometimes touch it up with an L1 to get it up in your face.