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You can run a mac as your sequencer(assuming your sequencer has VST or AU support), but yeah, the two sampler computers(one being the main controller for the library) have to be PC's... at least for now. Pricewise, I think that was a smart move. They spec out that you need a minimum of a core 2 quad processor for each PC, the only macs that currently meet this spec is the mac pro. If you build your own PC's, the price is a fraction of buying two mac pros. They kind of hint though that if and when they develop a mac version that it may be possible to run from a single 8 core mac pro. The current bottleneck is the FSB speed, but with every new version of the Mac Pro this has increased.
For me, the biggest question is if I'll be able to get this to work with Pro Tools. Using the FXpansion VST to RTAS adaptor I know it's possible to make muse research's uniwire plugin work, but there are many VST plugins that won't necessarily work with this. I can think of a few workarounds, but they would add more complexity and expense to my already complicated and expensive studio.
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