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i own the 4328 and love them. the mixes translate very well (although i tend to mix vocals a bit too loud, but thats easy to remember and change when listening on other speakers which is a must anyway)
as far as i know the signal always passes trough the dsp, so i would recommend using the spdif or aes/ebu, as otherwise you will have one DA and AD conversion more...
for level: optimal level in your daw, unity gain on audiocard (should be optimum) into the speakers...just be shure to be on the same nominal level (+4dbu or -10dbV) all the way from audiocard to speaker
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