Same thing here. Using my PT HD3 / G4 Dual 1.42 / OS-X for audio and midi w/external synths is stable as a rock. When it comes to soft synths and RTAS/HDTM instruments........all kind of strange things happen. I´m using Stylus, Garritan Personal Orchestra, B4 and Groove Agent (GA under VST-Wrapper).
I second Mr. Lambrechts point. I´ll just want to add that I find the RTAS versions of softsynths more stable than their HDTM counterpart.
I used to think of PT as the most stable piece of software out there. I´ve just recently begun using PT with softsynths (been using a dedicated PC for GigaSampler and VST-instruments, along with external hardware synths and samplers....remember those...

), and I must say the experience has been a mixed bag.
Now, I don´t want to go the Logic way. I still prefer keeping audio + midi in the same app. Anyone know if Digidesign has any plans of making softsynths more stable? Repeated questions on the DUC about this matter remains unanswered.
Stein Tore