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I've done this before. In particular, I worked on an album by an electro-pop/rock band (i guess that's what they'd be called) that every song had loooped drums with acoustic drums. The electronic parts were mostly done by the time I got involved. We recorded live drums to the electronic drums - then we used beat detective to tighten up everything. This was on a Mix+/OS9 PT system; it took a while to edit everything together. It can be done, and can be very cool. Don't be afraid to dive in and do everthing you think it might take to make it happen well.
As far as retracking other instrument ot fit the new groove - record the drums and then see how it works. It should be obvious if you need to re-record. If the drummer is very good - in my experience, probably not.
Ben
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